Aminobutyric Acid
Aminobutyric Acid
How do benzodiazepines work?
Wikipedia fails me again. They say that benzodiazepines enhance the inhibitory effects of gamma-aminobutyric but what does that mean? I am quite familiar with the neurotransmitters and others, and I agonize whether benzodiazepine GABA receptor, or what? No barbiturate nonbenzodiazepines and work the same way?
Benzo are GABA agonists. They do this by binding to a secondary site (subunit) in the receiver GABA and increasing the effectiveness of GABA at the opening of Cl-channels, which increases the inhibitory effect of this neurotransmitter. There are additional sites in the GABA receptor that alcohol and barbiturates bind. (This is why alcohol is dangerous, whether or barbiturates Benzo since the effects are synergistic and can cause respiratory depression / death etc.) In benzodiazepines increased inhibition of neurons relieve anxiety, and some are useful to control seizures (although barbiturates are more effective in this sense).
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